specfitlab

johns hopkins

baltimore, md

The specfitlab is part of the Division of MR Research in the Russell H. Morgan Department of Radiology and Radiological Science at Johns Hopkins University School of Medicine, and the F.M. Kirby Research Center for Functional Brain Imaging at Kennedy Krieger Institute. We work on new in-vivo magnetic resonance spectroscopy data acquisition and analysis techniques that we use to study the biochemistry of the human brain with a clinical MRI scanner.

Learn more about our research, our group members and our collaborators, or check out our latest publications.

If you would like to participate as a volunteer in one of our studies, please find all information here.

news

Jul 31, 2024	Lots of good news over the past few weeks: Chris Davies-Jenkins published two first-author papers on [modeling GABA-edited spectra with measured macromolecules(Magn Reson Med) as well as 7T MRS and PiB-PET amyloid measures in patients with mild cognitive impairment and late-life depression (Neurobiology of Aging) - fantastic work. Dunja Simicic published her paper on model-based frequency and phase correction (Magn Reson Med). We received the notice of award for a four-year R01 on “Model Selection for Magnetic Resonance Spectroscopy”, which will allow us to continue developing new tools to improve spectral fitting and uncertainty estimation with Osprey. Last but not least, we are lucky to have welcomed Dr. Seyma Alcicek, a visiting postdoctoral fellow from PD Dr. Katharina Wenger-Alakhmeh’s group at the University of Frankfurt. Seyma has tremendous expertise in brain tumor MRS and will contribute it to our ongoing collaboration with neurooncology.
Mar 31, 2024	We’re very excited to share Dunja Simicic’s pre-print on using 2D linear-combination modeling to directly integrate frequency-and-phase correction of individual transients. This exciting work is the first application of our new, completely overhauled Osprey modeling module first described in Helge’s (also brand-new at Magn Reson Med) paper. Very cool times ahead.
Mar 05, 2024	Helge has been promoted to Instructor of Radiology and Radiological Science!
Aug 31, 2023	Dr. Helge Zöllner has been awarded a highly prestigious and lucrative K99 Career Development Award from the National Institute on Aging entitled “Brain metabolism across the lifespan using multi-parametric MRS”. This is an outstanding reward for his ever-growing contributions and a fantastic opportunity. Congratulations, Helge!
Jul 14, 2023	Our paper on a continuous automated MRS data analysis workflow is now out - well done Helge!

latest posts

Feb 29, 2024	Quick little LCModel basis set plotter (MATLAB)
Jan 04, 2023	A Blog on In-Vivo Magnetic Resonance Spectroscopy
Oct 01, 2022	Roundup Q3 2022 - R21 Trailblazer, MRS Workshop 2022, HBCD study
Mar 04, 2022	New lab member, new paper!
Jul 31, 2021	Talk at Pediatric Imaging Research Center Pittsburgh